CDw17 (Lactosylceramide or LacCer) Antibody
Product Sizes
100 ug
£671.00
MSM2-1092-P1-100UG
About this Product
- SKU:
- MSM2-1092-P1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- HO18.3G-6.F5
- Clonality:
- Monoclonal
- Extra Details:
- CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes; granulocytes; basophils; platelets; a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17; which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor )-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
- Host:
- Mouse
- Immunogen:
- β-2 Microglobulin associated proteins from a detergent lysate of human PBL
- Isotype:
- IgM
- Molecular Weight:
- Not Known
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125850
