Thomsen-Friedenreich Antigen / CD176 (Pan Carcinoma Marker) Antibody
Product Sizes
100 ug
£671.00
MSM1X-936-P1-100UG
About this Product
- SKU:
- MSM1X-936-P1
- Application:
- Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- SPM320
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a disaccharide epitope; Gal 1-3GalNAc; of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF ; including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen; with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. This MAb is capable to agglutinate desialylated red blood cells.During metastasis; the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response; and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. The Thomsen-Friedenreich antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. The presence of the Thomsen-Friedenreich antigen on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells; most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.
- Host:
- Mouse
- Immunogen:
- Neuraminidase-treated human red blood cells
- Isotype:
- IgM
- Molecular Weight:
- Multiple
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125822
