Myofibroblast Marker Antibody
Product Sizes
100 ug
£671.00
MSM1-3069-P1ABX-100UG
About this Product
- SKU:
- MSM1-3069-P1ABX
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- PR 2D3
- Clonality:
- Monoclonal
- Extra Details:
- Myofibroblasts are a unique group of smooth muscle-like fibroblasts that play an important role in oncogenesis; inflammation; repair; wound contraction and fibrosis. Like smooth muscle (SM) cells; myofibroblasts contain microfilament bundles and express -SM Actin; the Actin isoform that is present in myoepithelial cells and SM cells and especially abundant in vascular SM cells. Myofibroblasts secrete inflammatory and anti-inflammatory cytokines; chemokines; growth factors and lipid and gaseous inflammatory mediators; as well as extracellular matrix proteins and proteases in most organs and tissues. Besides being temporarily present following tissue injuries and fibrocontractive diseases; myofibroblasts are also present under normal conditions in regions such as the skin; pulmonary septa and periodontal ligaments. Stem cell factor and platelet-derived growth factor (PDGF) are two secreted proteins responsible for differentiating myofibroblasts from embryological stem cells. PR 2D3 reacts with a cell membrane component of cells in the pericrypt sheath; with smooth muscle cells and myofibroblasts. This antibody is considered to be the gold standard for the identification of myofibroblasts.
- Host:
- Mouse
- Immunogen:
- Crude homogenate of normal human colorectal mucosa
- Isotype:
- IgG1
- Molecular Weight:
- 28kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125554
