Cig2 Antibody
Product Sizes
100 ug
£671.00
MSM1-2827-P1-100UG
About this Product
- SKU:
- MSM1-2827-P1
- Application:
- ELISA, Western Blot
- translate.label.attr.clone:
- 3A11/5
- Clonality:
- Monoclonal
- Extra Details:
- Cig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type; S phase cyclin that is required for both the G1/S and G2/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1/S period. Cig2 binds to Cdc2 (Cdk); and the resulting Cdc2/Cig2 complex controls the G1/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF); and the protein is destroyed during anaphase by the APC/cyclosome (APC/C) and Skp1/Cullin-1/F-box (SCF); thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner; transcriptionally and post-translationally; while APC/C only destroys the protein.
- Host:
- Mouse
- Immunogen:
- Bacterial S. pombe Cig2 Purified protein.
- Isotype:
- IgG1
- Molecular Weight:
- ~50kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125528
