Clostridium difficile (Toxin A) Antibody
Product Sizes
20 ug
£364.00
MSM1-202-P0-20UG
About this Product
- SKU:
- MSM1-202-P0
- Application:
- ELISA, Immunofluorescence
- translate.label.attr.clone:
- 253/422
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with C. difficile Toxin A; but not with Cholera subunit a; Cholera toxin; Pseudomonas aeruginosa exotoxin A; H-LT; P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21; leading to cytochrome c release and caspase-3 activation through Bak activation.
- Host:
- Mouse
- Immunogen:
- C. difficile Toxin A
- Isotype:
- IgG1
- Molecular Weight:
- 308kDa (Toxin A)
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125491
