GITR / Tnfrsf18 (Mouse) Antibody
Product Sizes
100 ug
£671.00
MS21936-RTM1-P1ABX-100UG
About this Product
- SKU:
- MS21936-RTM1-P1ABX
- Additional Names:
- Glucocorticoid-induced TNFR-related protein
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- DTA-1
- Clonality:
- Monoclonal
- Extra Details:
- GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily; also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation; proliferation; cytokine production as well as MAPKs and NF-B activation; and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
- Host:
- Rat
- Immunogen:
- Mouse CD25+ CD4+ T cells
- Isotype:
- IgG2b
- Molecular Weight:
- 66-70kDa (Homodimer)
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125432
