E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) Antibody
Product Sizes
100 ug
£671.00
999-MSM4-P1ABX-100UG
About this Product
- SKU:
- 999-MSM4-P1ABX
- Additional Names:
- CAM 120/80 | Epithelial cadherin | Uvomorulin
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- 4A2
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 120-80kDa; identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins; E-; N- and P-cadherin; consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins; such as 尾-catenin; to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer; prostate and esophageal cancer. In combination with p120 Catenin; it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
- Host:
- Mouse
- Immunogen:
- Recombinant human E-Cadherin protein
- Isotype:
- IgG1
- Molecular Weight:
- 120-80kDa (Mature); 135kDa (Precursor)
- Research Area:
- Bladder Cancer; Cardiovascular; Colon Cancer; Developmental Biology; Immunology; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125372
