Major Vault Protein (MVP) Antibody
Product Sizes
100 ug
£671.00
9961-MSM1-P1-100UG
About this Product
- SKU:
- 9961-MSM1-P1
- Additional Names:
- Lung resistance-related protein
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- 1014
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 104kDa-110kDa; characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology; including several small molecules of RNA; but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen; progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
- Host:
- Mouse
- Immunogen:
- proteins precipitated from human breast cancer MCF-7 cells
- Isotype:
- IgG1
- Molecular Weight:
- 104-110kDa
- Research Area:
- Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=125317
