CD59 / Complement Regulatory Protein / Protectin Antibody
Product Sizes
100 ug
£671.00
966-MSM4-P1BX-100UG
About this Product
- SKU:
- 966-MSM4-P1BX
- Additional Names:
- 1F5 antigen | 20 kDa homologous restriction factor | MAC-inhibitory protein | MEM43 antigen | Membrane attack complex inhibition factor | Membrane inhibitor of reactive lysis | Protectin
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MACIF/1193
- Clonality:
- Monoclonal
- Extra Details:
- Reacts with human CD59; a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis; and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex; whereby it binds complement C8 and/or C9 during the assembly of this complex; thereby inhibiting the incorporation of multiple copies of C9 into the complex; which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC; thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment; that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). It is useful for study on GPI-anchored proteins; PNH and CD59 functions.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CD59 protein
- Isotype:
- IgM
- Molecular Weight:
- 20kDa
- Research Area:
- Complement System; Hematopoietic Stem Cells; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124987
