CD53 (TSPAN25) Antibody
Product Sizes
20 ug
£364.00
963-MSM2-P0-20UG
About this Product
- SKU:
- 963-MSM2-P0
- Additional Names:
- Cell surface glycoprotein CD53 | Tetraspanin-25
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- 161-2
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 33-55kDa; identified as CD53 (Workshop VI; Code N-L033). It is expressed on monocytes and macrophages; dendritic cells; osteoblasts and osteoclasts; and on T and B cells from every stage of differentiation but is absent from platelets; red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. CD53 is a type III membrane with both termini in the cytoplasm and two loops in the extracellular environment. This molecule; in common with other members of tetraspan family; is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. CD53 crosslinking induces calcium flux on human monocyte and B cells. Cross-linking of CD53 promotes activation of resting human B-lymphocytes. This MAb recognizes CD53 transfected cells and partially inhibits T-cell proliferation induced by CD3 antibody (clone: UCHT1).
- Host:
- Mouse
- Immunogen:
- Stimulated human leukocytes
- Isotype:
- IgG2a
- Molecular Weight:
- 33-55kDa
- Research Area:
- Cardiovascular; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124982
