CD40 Ligand / CD154 / TRAP1 (Activation Marker of T-Lymphocytes) Antibody
Product Sizes
100 ug
£671.00
959-MSM3-P1ABX-100UG
About this Product
- SKU:
- 959-MSM3-P1ABX
- Additional Names:
- T-cell antigen Gp39 | TNF-related activation protein | Tumor necrosis factor ligand superfamily member 5
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- CD40LG/2763
- Clonality:
- Monoclonal
- Extra Details:
- CD40LG expression is mainly confined to the CD4-positive-T-cell subset. Its expression is induced shortly after T-cell activation and represents an early activation marker of T lymphocytes. CD40 is constitutively expressed mainly on B cells; macrophages; and dendritic cells. The CD40-CD40L pathway has been shown to play multiple functional roles in the healthy immune system. It enhances the antigen-specific T-cell response through the activation of dendritic cells and the induction of interleukin-12 production. For example; engagement of CD40 on endothelial cells by activated T cells expressing CD40L leads to upregulation of adhesion molecules such as ICAM-1; VCAM-1; and E-selectin. Activation of APC by CD40-CD40L interaction induces the production of inflammatory cytokines; chemokines; NO; and metalloproteinases. Interaction of CD4-positiveCD40LG-positiveT cells with CD40 on B cells leads to B-cell differentiation; proliferation; immunoglobulin (Ig) isotype switching; and formation of memory B cells.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human CD40LG protein (around aa 108-261) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 36kDa
- Research Area:
- AKT Signaling; Apoptosis; Autophagy; Cardiovascular; Cytokine Signaling; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124804
