WTAP Antibody
Product Sizes
100 ug
£671.00
9589-MSM1-P1ABX-100UG
About this Product
- SKU:
- 9589-MSM1-P1ABX
- Additional Names:
- Female-lethal(2)D homolog | WT1-associated protein | Wilms tumor 1-associating protein
- Application:
- Flow Cytometry, Immunohistochemistry
- translate.label.attr.clone:
- PCRP-WTAP-1A4
- Clonality:
- Monoclonal
- Extra Details:
- Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10;000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG; a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators; and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles; where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2; thus enhancing its stability. Additionally; WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human WTAP protein
- Isotype:
- IgG2b
- Molecular Weight:
- 44.2kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135254
