Recombinant CD40 / TNFRSF5 / CD40L-Receptor Antibody
Product Sizes
20 ug
£364.00
958-RBM6-P0-20UG
About this Product
- SKU:
- 958-RBM6-P0
- Additional Names:
- B-cell surface antigen CD40 | Bp50 | CD40L receptor | CDw40
- Application:
- ELISA, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- C40/4826R
- Clonality:
- Monoclonal
- Extra Details:
- CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching; memory B cell development; and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand; which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation; and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes; follicular dendritic cells; bone marrow-derived dendritic cells; thymic epithelium; and interdigitating cells in the T-cell zones of secondary lymphoid organs.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human CD40 protein (around aa 29-107) (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 43kDa
- Research Area:
- AKT Signaling; B Cell Markers; Cardiovascular; Complement System; Cytokine Signaling; Immune checkpoint; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124801
