Recombinant CD39 / ENTPD1 (Marker of Tumor-specific T cells) Antibody
Product Sizes
100 ug
£671.00
953-MSM7-P1-100UG
About this Product
- SKU:
- 953-MSM7-P1
- Additional Names:
- Ecto-ATP diphosphohydrolase 1 | Ecto-apyrase | Lymphoid cell activation antigen
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- r22A9
- Clonality:
- Monoclonal
- Extra Details:
- CD39 is a transmembrane glycoprotein and an extracellular nucleotide-hydrolyzing enzyme that plays a key role in regulating extracellular ATP and ADP levels. Also known as E-type apyrase; CD39 hydrolyzes ATP and ADP to AMP; which is further converted to adenosine. By degrading ADP; CD39 inhibits platelet aggregation; contributing to its anti-thrombotic function and potential use in preventing coronary artery occlusion and thrombotic stroke. Intracellularly; CD39 undergoes glycosylation at six N-glycosylation sites before translocating to the membrane to become an active enzyme. Alternative splicing gives rise to three isoforms: vascular; placenta I; and placenta II; with variations at the N-terminus and C-terminus. CD39 is expressed in vascular tissues; including the placenta; lung; skeletal muscle; and kidney; as well as on endothelial cells; smooth muscle cells; cardiac cells; and platelets. In the immune system; CD39 is present on activated B cells; a subset of activated T cells; activated NK cells; macrophages; dendritic cells; and Langerhans cells. It is not expressed on resting lymphocytes but is found in lymphoid tissues; particularly in the mantle zone and paracortical lymphocytes. CD39-expressing cells may provide protection to lymphocytes from the toxic effects of ATP released from damaged cells. Originally identified on Epstein-Barr virus-transformed B cells; CD39 is now recognized as a key immunoregulatory enzyme involved in inflammation; immune suppression; and thrombotic balance.
- Host:
- Mouse
- Immunogen:
- Prokaryotic recombinant protein corresponding to a portion of the external domain of the CD39 molecule
- Isotype:
- IgG2a
- Molecular Weight:
- 70-100 kDa
- Research Area:
- Immuno Oncology; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=141512
