Recombinant CD34 (Hematopoietic Stem Cell & Endothelial Marker) Antibody
Product Sizes
100 ug
£671.00
947-RBM27-P1ABX-100UG
About this Product
- SKU:
- 947-RBM27-P1ABX
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- HPCA1/8353R
- Clonality:
- Monoclonal
- Extra Details:
- CD34 (also named myeloid progenitor cell antigen) is a heavily glycosylated type I transmembrane protein. There are two forms of the CD34 protein; resulting from alternative splicing. The functions of CD34 is largely unknown; but recent evidence suggests a role for CD34 in cell adhesion and inhibition of hematopoiesis. It is suggested that CD34 is a signaling molecule involved in maintenance of a phenotypically plastic state in undifferentiated cells. CD34 is found in most endothelia; expressed on the luminal surface and membrane processes interdigitating between endothelial cells; but is absent from large veins and arteries. CD34 is furthermore expressed in fibroblast-like dendritic cells in; e.g.; portal tracts of the liver; Peyer's patches; and in healing wounds. In smooth muscle cells; a variable CD34 staining is found. In tumor tissues; CD34 is detected in myeloid blasts in myelodysplastic syndrome and acute myeloid leukemia in most cases as well as lymphoblasts in most cases of B-acute lymphoblastic leukemia. Mature B- and T-cell lymphomas and leukemias are CD34 negative. The majority of vascular tumors; including hemangiosarcoma and Kaposi sarcoma are CD34positive. In a panel; CD34 staining is useful for the classification of myeloid and lymphoid neoplasms as well as spindle cell neoplasms (particularly identification of gastrointestinal stromal tumor and hemangiosarcoma).
- Host:
- Rabbit
- Immunogen:
- Recombinant full-length human CD34 protein
- Isotype:
- IgG
- Molecular Weight:
- 41kDa
- Research Area:
- Endothelial Cell Marker; Hematopoietic Stem Cells; Immunology; Mesenchymal Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130426
