CD33 / SIGLEC3 (Myeloid Cell Surface Antigen) Antibody
Product Sizes
100 ug
£671.00
945-MSM10-P1-100UG
About this Product
- SKU:
- 945-MSM10-P1
- Additional Names:
- Sialic acid-binding Ig-like lectin 3 | gp67
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SIGLEC3/3600
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a 67kDa glycoprotein; which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage; binds sialic acid residues in N- and O-glycans on cell surfaces; and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors; monocytes; granulocytes; dendritic cells and mast cells. It is absent on platelets; lymphocytes; erythrocytes and hematopoietic stem cells.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa51-224) of human CD33 protein (exact sequence is proprietary)
- Isotype:
- IgG2c
- Molecular Weight:
- ~67kDa
- Research Area:
- Hematopoietic Stem Cells; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124594
