QKI / Protein Quaking Antibody
Product Sizes
100 ug
£671.00
9444-MSM1-P1ABX-100UG
About this Product
- SKU:
- 9444-MSM1-P1ABX
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-QKI-2F10
- Clonality:
- Monoclonal
- Extra Details:
- QKI; also known as HKQ; QK; QK3 or quaking; is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain; QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1;20)-UAAY-3'. Additionally; QKI regulates pre-mRNA splicing; and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus; an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human QKI protein
- Isotype:
- IgG2c
- Molecular Weight:
- 37.6kDa
- Research Area:
- Cardiovascular; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124592
