MED7 Antibody
Product Sizes
20 ug
£364.00
9443-MSM1-P0-20UG
About this Product
- SKU:
- 9443-MSM1-P0
- Additional Names:
- Activator-recruited cofactor 34 kDa component | Cofactor required for Sp1 transcriptional activation subunit 9 | Mediator complex subunit 7 | RNA polymerase transcriptional regulation mediator subunit 7 homolog | Transcriptional coactivator CRSP33
- Application:
- ELISA, Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-MED7-1B8
- Clonality:
- Monoclonal
- Extra Details:
- MED7; also known as HKQ; QK; QK3 or quaking; is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain; MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1;20)-UAAY-3'. Additionally; MED7 regulates pre-mRNA splicing; and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus; an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MED7 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 27.2kDa
- Research Area:
- Developmental Biology; Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124591
