MED21 / SRB7 Antibody
Product Sizes
100 ug
£671.00
9412-MSM1-P1ABX-100UG
About this Product
- SKU:
- 9412-MSM1-P1ABX
- Additional Names:
- Mediator complex subunit 21 | RNA polymerase II holoenzyme component SRB7
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-MED21-4B5
- Clonality:
- Monoclonal
- Extra Details:
- In mammalian cells; transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase. These complexes include the SMCC (SRB and MED protein cofactor complex); which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes and including the human proteins Srb7; Med6 (also designated DRIP33) and Med7 (also designated DRIP34). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and; in turn; enhances gene-specific activation or repression induced by DNA-binding transcription factors. Med6 and Med7; as well as other components of SMCC; associate with co-activator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation. Additionally; SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human MED21 protein
- Isotype:
- IgG1
- Molecular Weight:
- 15.5kDa
- Research Area:
- Developmental Biology; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124476
