CD163 (Monocyte & Macrophage Marker) Antibody
Product Sizes
100 ug
£671.00
9332-MSM3-P1-100UG
About this Product
- SKU:
- 9332-MSM3-P1
- Additional Names:
- Hemoglobin scavenger receptor
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- M130/2163
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 140kDa; identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages; histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis; where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes); gut; Kupffer cells; a few alveolar macrophages; macrophages in the placenta; and in macrophages in inflamed tissues including tumor tissue.
- Host:
- Mouse
- Immunogen:
- Recombinant human CD163 fragment (around aa 43-196) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 140kDa
- Research Area:
- Cardiovascular; Dendritic Cell Marker; Hematopoietic Stem Cells; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124354
