Recombinant CD19 (B-Lymphocyte Marker) Antibody
Product Sizes
20 ug
£364.00
930-RBM49-P0-20UG
About this Product
- SKU:
- 930-RBM49-P0
- Additional Names:
- B-lymphocyte surface antigen B4 | Differentiation antigen CD19 | T-cell surface antigen Leu-12
- Application:
- ELISA
- translate.label.attr.clone:
- CD19/13031R
- Clonality:
- Monoclonal
- Extra Details:
- CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue; CD19 is observed in germinal centers; in mantle zone cells; and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However; in contrast to CD20; expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative; as are T-cell neoplasms. CD19 antibody binds to the human CD19 protein; a transmembrane protein expressed in all B lineage cells including human plasma cells. CD19 plays two major roles in human B cells: it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane and works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. CD19 is a biomarker for B lymphocyte development; lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.
- Host:
- Rabbit
- Immunogen:
- Recombinant human CD19 protein
- Isotype:
- IgG
- Molecular Weight:
- 95kDa
- Research Area:
- B Cell Markers; Cardiovascular; Complement System; Hematopoietic Stem Cells; Immune checkpoint; Immunology; Infectious Disease; Mesenchymal Stem Cell Differentiation; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=138049
