CD8A (Cytotoxic- & Suppressor T-Cell Marker) Antibody
Product Sizes
100 ug
£671.00
925-RBP4-P1-100UG
About this Product
- SKU:
- 925-RBP4-P1
- Additional Names:
- T-lymphocyte differentiation antigen T8/Leu-2
- Application:
- Flow Cytometry, Immunohistochemistry
- Clonality:
- Polyclonal
- Extra Details:
- CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells; CD4 and CD8 are mutually exclusive; so anti-CD8; generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes; and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-; and in T-lymphoblastic lymphoma/leukemia; CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment from human CD8 C-terminal cytoplasmic domain of alpha chain (exact sequence is proprietary).
- Isotype:
- IgG
- Molecular Weight:
- 32kDa
- Research Area:
- Cardiovascular; Dendritic Cell Marker; Hematopoietic Stem Cells; Immunology; PD-1 blockade immunotherapy
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. ;Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124117
