CD8A (Cytotoxic / Suppressor T-Cell Marker) Antibody
Product Sizes
20 ug
£364.00
925-MSM5-P0-20UG
About this Product
- SKU:
- 925-MSM5-P0
- Additional Names:
- T-lymphocyte differentiation antigen T8/Leu-2
- Application:
- ELISA, Flow Cytometry
- translate.label.attr.clone:
- C8/1035
- Clonality:
- Monoclonal
- Extra Details:
- CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells; CD4 and CD8 are mutually exclusive; so anti-CD8; generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes; and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-; and in T-lymphoblastic lymphoma/leukemia; CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CD8a protein
- Isotype:
- IgG1
- Molecular Weight:
- 32kDa
- Research Area:
- Cardiovascular; Dendritic Cell Marker; Hematopoietic Stem Cells; Immuno Oncology; Immunology; PD-1 blockade immunotherapy
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=124110
