Recombinant CD5 (Mantle Cell Lymphoma Marker) Antibody
Product Sizes
100 ug
£671.00
921-MSM16-P1-100UG
About this Product
- SKU:
- 921-MSM16-P1
- Additional Names:
- Lymphocyte antigen T1/Leu-1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rC5/6976
- Clonality:
- Monoclonal
- Extra Details:
- The CD5 antigen is a transmembrane glycoprotein expressed on the surface of practically all mature human T-cells (about 10% of CD4+ T-cells being CD5 negative). In immature (CD34+) T-cells; CD5 is weakly expressed; the intensity of expression increaing with maturation. CD5 is also expressed in a small subset of normal human B-cells (20% of B-cells in the peripheral blood; scattered cells in the lymph node mantle zone). The CD5+ cells are probably involved in B-T interaction and their ligand is CD72 which is expressed on all B cells. It appears that CD5+ B-cells on activation primarily produce IgM. They also produce more autoantibodies than normal CD5 negative B-cells. Thus; the CD5+ B-cell population is expanded in rheumatoid arthrititis and systemic lupus erythematosus. The CD5 antibody reacts with CD5 expressed on B and T cells; and may be a useful aid for theclassification of B and T-cell malignancies. This includes B-cell chronic lymphoid leukemia (B-CLL); B-cell small lymphocytic lymphoma (B-SLL); mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia.
- Host:
- Mouse
- Immunogen:
- Recombinant human protein fragment corresponding to CD5 extracellular domain
- Isotype:
- IgG1
- Molecular Weight:
- 67kDa
- Research Area:
- B Cell Markers; Hematopoietic Stem Cells
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=129912
