CD3D / T Cell Receptor delta Antibody
Product Sizes
100 ug
£671.00
915-MSM1-P1ABX-100UG
About this Product
- SKU:
- 915-MSM1-P1ABX
- Additional Names:
- T-cell receptor T3 delta chain
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CD3D/8898
- Clonality:
- Monoclonal
- Extra Details:
- The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge); a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g; e and d chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast; the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-171) of human CD3D protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 20kDa
- Research Area:
- Cardiovascular; Immunology; PD-1 blockade immunotherapy
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128149
