Cyclin B2 Antibody
Product Sizes
100 ug
£671.00
9133-MSM1-P1ABX-100UG
About this Product
- SKU:
- 9133-MSM1-P1ABX
- Application:
- ELISA
- translate.label.attr.clone:
- X29.2
- Clonality:
- Monoclonal
- Extra Details:
- In eukaryotic cells; mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor; M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2); a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). The Cdc/cyclin enzyme is subject to multiple levels of control; of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme; and tyrosine dephosphorylation; occurring at the onset of mitosis; directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase; but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase; of which Cdc2 is the physiological substrate. The two B type cyclins; cyclin B1 and cyclin B2; have been shown to have distinct tissue distributions.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length Xenopus laevis Cyclin B2 protein
- Isotype:
- IgG1
- Molecular Weight:
- 51kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123721
