N myc (and STAT) Interactor / NMI Antibody
Product Sizes
20 ug
£364.00
9111-MSM1-P0-20UG
About this Product
- SKU:
- 9111-MSM1-P0
- Additional Names:
- N-myc and STAT interactor
- Application:
- Flow Cytometry
- translate.label.attr.clone:
- PCRP-NMI-1C1
- Clonality:
- Monoclonal
- Extra Details:
- Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors; including c-Myc; n-Myc; Max; and c-Fos; which contain bHLH-ZIP; bHLH; or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins; Nmi also associates with the Stat family of transcription factors; where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain; Nmi enhances the transcriptional activity of the Stat proteins; in response to cytokine stimulation; by recruiting the Stat1 and Stat5 transcriptional coactivators; CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi; expressed in conjunction with CBP; enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human NMI protein
- Isotype:
- IgG2b
- Molecular Weight:
- 38kDa
- Research Area:
- Cardiovascular; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123697
