SIGLEC10 Antibody
Product Sizes
100 ug
£671.00
89790-MSM2-P1-100UG
About this Product
- SKU:
- 89790-MSM2-P1
- Additional Names:
- Siglec-like protein 2
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SIGLEC10/7582
- Clonality:
- Monoclonal
- Extra Details:
- Siglec-10 (sialic acid-binding Ig-like lectin 10) is a 697 amino acid protein belonging to the immunoglobulin superfamily. The N-terminal Ig-like domain of Siglec-10 contains a sialic acid-binding site and the C-terminal cytoplasmic region of Siglec-10 contains two immunoreceptor tyrosine-based inhibitor motifs (ITIMs); which are involved in the modulation of cellular responses through SH2 domains. With most expression in spleen; bone marrow and peripheral blood lymphocytes; such as monocytes; natural killer cells and eosinophils; it is likely that Siglec-10 functions as an inhibitory receptor in the immune response. Importantly; Siglec-10 mRNA is found to be highly upregulated in eosinophils at sites of inflammation in asthmatics; suggesting that Siglec-10 may be an appropriate target for new approaches of immunomodulatory therapy. There are six named isoforms of Siglec-10 that are a result of alternative splicing. All isoforms exists as single-pass transmembrane proteins; except for isoform 6; which is secreted.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa500-697) of human SIGLEC10 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 77kDa
- Research Area:
- Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=132306
