Recombinant Cyclin B1 (G2- & M-phase Cyclin) Antibody
Product Sizes
20 ug
£364.00
891-RBM9-P0-20UG
About this Product
- SKU:
- 891-RBM9-P0
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CCNB1/9242R
- Clonality:
- Monoclonal
- Extra Details:
- In eukaryotic cells; mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor; M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2); a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). The Cdc/cyclin enzyme is subject to multiple levels of control; of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme; and tyrosine dephos phorylation; occurring at the onset of mitosis; directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase; but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase; of which Cdc2 is the physio logical substrate. The specificity of this effect is shown by the inability of either cyclin A or cyclin D1 to display any such stimulation of Cdc25A or Cdc25B.
- Host:
- Rabbit
- Immunogen:
- His-tagged recombinant hamster CCNB1 protein
- Isotype:
- IgG
- Molecular Weight:
- 55-62kDa
- Research Area:
- Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=134208
