CD133 / Prominin (Cancer Stem Cell Marker) Antibody
Product Sizes
20 ug
£364.00
8842-MSM1-P0-20UG
About this Product
- SKU:
- 8842-MSM1-P0
- Additional Names:
- Antigen AC133 | Prominin-like protein 1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PROM/1510
- Clonality:
- Monoclonal
- Extra Details:
- CD133; also known as PROML1 or Prominin; is a stem cell antigen that may be useful for the selection and expansion of hematopoietic cells and may be used as a positive marker for the characterization of trophoblast cell lines. The human CD133 gene maps to chromosome 4p15.32 and encodes an 865 amino acid protein. The CD133 gene codes for a pentaspan transmembrane glycoprotein that is expressed on primitive hematopoietic stem; progenitor; retinoblastoma; hemangioblasts and neural stem cells and developing epithelium. The 5-TM structure includes an extracellular N-terminus; two short intra- cellular loops; two large extracellular loops and an intracellular C-terminus. CD133 is a candidate gene for retinal proteins that are targeted to plasma membrane protrusions. These retinal proteins; including CD133; may influence the shedding of photoreceptive membranes from the terminal end of the outer segments of vertebrate photoreceptors; where they are phagocytosed by the retinal pigment epithelium; and represent candidates for inherited retinal degenerations.
- Host:
- Mouse
- Immunogen:
- Recombinant chimeric PROM1 protein (around aa180-380 and aa612-765). This Mab recognizes both glycosylated and non-glycosylated extracellular domains of CD133.
- Isotype:
- IgG2
- Molecular Weight:
- 97kDa. Depending upon glycosylation|the apparent molecular weight on western blots will increase to
- Research Area:
- Neural Stem Cells; Stem Cell Differentiation
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=132304
