CD262 / DR5 Antibody
Product Sizes
100 ug
£671.00
8795-MSM1-P1ABX-100UG
About this Product
- SKU:
- 8795-MSM1-P1ABX
- Additional Names:
- Death receptor 5 | TNF-related apoptosis-inducing ligand receptor 2 (TRAIL receptor 2; TRAIL-R2) | CD262
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- DR5/3381
- Clonality:
- Monoclonal
- Extra Details:
- Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors; designated TNF-R1 and TNF-R2; which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes Fas antigen and CD40. TNF-R1 contains a cytoplasmic motif; termed the death domain ; that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors; including Fas; DR2 (or TRUNDD); DR3 (death receptor 3); DR4 and DR5. TRUNDD; DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor; designated decoy receptor (DcR1 or TRID); also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.
- Host:
- Mouse
- Immunogen:
- Recombinant human DR5 protein fragment (around aa266-393) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 48kDa
- Research Area:
- AKT Signaling; Apoptosis; Autophagy; Cardiovascular; Ovarian Cancer; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123514
