CBFB / PEBP2β Antibody
Product Sizes
100 ug
£671.00
865-MSM1-P1ABX-100UG
About this Product
- SKU:
- 865-MSM1-P1ABX
- Additional Names:
- Polyomavirus enhancer-binding protein 2 beta subunit | SL3-3 enhancer factor 1 subunit beta | SL3/AKV core-binding factor beta subunit
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-CBFB-1F6
- Clonality:
- Monoclonal
- Extra Details:
- The transcription factor polyomavirus enhancer binding protein 2 (PEBP2); also designated Osf2 (osteoblast-specific transcription factor); CBFA1 (core binding factor) and AML3 (acute myeloid leukemia); is composed of two subunits; 伪 and 尾; which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2伪 subunits; PEBP2伪A; PEBP2伪B and PEBP2伪C; are encoded by three RUNX genes; all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene; Runt. This region is involved in DNA binding and heterodimerization with the regulatory 尾 subunit; which facilitates DNA binding of the 伪 subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2尾 is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle Myosin heavy chain; producing a chimeric gene; PEBP2尾/CBFB-SMMHC; that is associated with human acute myeloid leukemia.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CBFB protein
- Isotype:
- IgG2b
- Molecular Weight:
- 22kDa
- Research Area:
- Cardiovascular; Developmental Biology; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123486
