Recombinant p40 (deltaNp63) (Squamous; Basal & Myoepithelial Cell Marker) Antibody
Product Sizes
0.5 ml at 100ug/ml
£671.00
8626-RBM11-B1-0.5MLAT100UG
About this Product
- SKU:
- 8626-RBM11-B1
- Additional Names:
- Chronic ulcerative stomatitis protein | Keratinocyte transcription factor KET | Transformation-related protein 63 | Tumor protein p73-like | p40 | p51
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- TP40/3980R
- Clonality:
- Monoclonal
- Extra Details:
- p63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53; which regulates the expression of the growth-inhibitory genes. In contrast; DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain; which antagonizes the activity of TAp63 and p53. P40/3980R recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins; but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker; which has similar sensitivity and specificity as that of p63 antibody. Therefore; p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide from the N-terminal of human p40 protein (Exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 40kDa
- Research Area:
- Basal Cell Marker; Nuclear Marker; Stem Cell Differentiation; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=140572
