ABCC11 / ATP Binding Cassette Subfamily C Member 11 Antibody
Product Sizes
20 ug
£364.00
85320-MSM2-P0-20UG
About this Product
- SKU:
- 85320-MSM2-P0
- Additional Names:
- Multidrug resistance-associated protein 8
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- ABCC11/2438
- Clonality:
- Monoclonal
- Extra Details:
- ATP-binding cassette (ABC) transporters belong to an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies; designated ABC1; MDR/TAP; MRP; ALD; OABP; GCN20 and White. The complete human ABCC subfamily has 12 identified members (ABCC1-12); nine from the multidrug resistance-like subgroup; two from the sulfonylurea receptor subgroup; and the CFTR gene. The human ABCC11 gene maps to chromosome 16q12.1 and encodes a 1;382 amino acid protein. The human ABCC12 gene maps to chromosome 16q12.1 and encodes a 1;359 amino acid protein. Transcripts of ABCC11 and ABCC12 genes are present in various adult human tissues; including liver; lung and kidney; and also in several fetal tissues. Their chromosomal localization; potential function and expression patterns identify them as candidates for paroxysmal kinesigenic choreoathetosis; a disorder characterized by attacks of involuntary movements and postures; chorea and dystonia. Other inherited disorders where ABC transporters are implicated include cystic fibrosis; neurological disease; retinal degeneration; cholesterol and bile transport defects; anemia and drug response.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa400-600) of human ABCC11 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 170-190kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=132515
