Recombinant TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) Antibody
Product Sizes
100 ug
£1980.00
84868-RBM18-P1-100UG
About this Product
- SKU:
- 84868-RBM18-P1
- Additional Names:
- T-cell immunoglobulin and mucin domain-containing protein 3 | T-cell immunoglobulin mucin receptor 3 | T-cell membrane protein 3
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MSVA-366R
- Clonality:
- Monoclonal
- Extra Details:
- TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ ÔøΩTh1 and CD8+ ÔøΩTc1) but not on helper T cells (CD4+ ÔøΩTh2 and CD8+ ÔøΩTc2). In chronic inflammation; autoimmune disorders; and some cancers; TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production; Th1 cell proliferation and cytotoxicity; regulatory T cell development; and increases in macrophage and neutrophil infiltration into sites of inflammation.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human TIM3 protein (around aa1-200) (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 60kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=147569
