CASP7 / Caspase-7 Antibody
Product Sizes
100 ug
£671.00
840-MSM1-P1-100UG
About this Product
- SKU:
- 840-MSM1-P1
- Additional Names:
- Apoptotic protease Mch-3 | CMH-1 | ICE-like apoptotic protease 3
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CASP7/9051
- Clonality:
- Monoclonal
- Extra Details:
- A unique family of Cysteine proteases has been described that differs in sequence; structure and substrate specificity from any previously described protease family. This family; CED-3/caspase-1; is comprised of caspase-1; caspase-2; caspase-3; caspase-4; caspase-6; caspase-7 (also designated Mch3; ICE-LAP3 or CMH-1); caspase-9 and caspase-10. CED-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3; caspase-7 and caspase-9; but not caspase-1; have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6; but not caspase-3; has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human CASP7 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 28-34kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Complement System; Ovarian Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody w2ithout azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=127426
