Caspase 3 (Pro & Active Form) Antibody
Product Sizes
20 ug
£364.00
836-MSM2-P0-20UG
About this Product
- SKU:
- 836-MSM2-P0
- Additional Names:
- Apopain | Cysteine protease CPP32 | Protein Yama | SREBP cleavage activity 1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CASP3/8446
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 32kDa; identified as Caspase 3. It is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp 175-Ser 176 to produce the p11 subunit and the p20 peptide. Subsequently; the p20 peptide is cleaved at Asp 28-Ser 29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 sub- units. At the onset of apoptosis; caspase-3 proteolytically cleaves PARP at a Asp 216-Gly 217 bond. During the execution of the apoptotic cascade; activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6; -7 and -9.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human CASP3 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 32kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Colon Cancer; Complement System; Cytokine Signaling; Immunology; Lung Cancer; MAPK Signaling; Mitochondria Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135851
