Recombinant Histone H3; phosphorylated (pSer10) (Nuclear Marker) Antibody
Product Sizes
20 ug
£364.00
8350-RBM1-P0-20UG
About this Product
- SKU:
- 8350-RBM1-P0
- Additional Names:
- Histone H3/a | Histone H3/b | Histone H3/c | Histone H3/d | Histone H3/f | Histone H3/h | Histone H3/i | Histone H3/j | Histone H3/k | Histone H3/l
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- PHH3/471R
- Clonality:
- Monoclonal
- Extra Details:
- Phosphohistone H3 (PHH3) is a marker specific for cells undergoing mitosis. Serine 10 of Histone H3 is phosphorylated in association with mitotic chromatin condensation in late G2 and M phase of the cell cycle and thus; PHH3 can distinguish mitosis from apoptotic nuclei. The range of percentage PHH3 positive tumor nuclei was from 0.0 to 6.6% (median value 0.8%). Increased expression of PHH3 was significantly associated with tumor thickness (p = 0.031); presence of tumor ulceration (p =0.041) and tumor necrosis (p =0.027); but not with Clark's level of invasion. High levels of PHH3 was associated with increased mitotic count (p = 0.003) and high Ki-67 expression (p = 0.002). For central nervous system tumors; melanoma; soft tissue tumors; GIST; etc.; PHH3 mAb is helpful for tumor pathological classification and prognosis.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to (ARK-pS-TGGKAPRKQLc) of Phosphohistone H3 (phospho S10)
- Isotype:
- IgG
- Molecular Weight:
- 15kDa
- Research Area:
- Cytokine Signaling; Developmental Biology; Immunology; Infectious Disease; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123362
