Calpastatin Antibody
Product Sizes
100 ug
£671.00
831-MSM1-P1-100UG
About this Product
- SKU:
- 831-MSM1-P1
- Additional Names:
- Calpain inhibitor | Sperm BS-17 component
- Application:
- ELISA, Immunohistochemistry
- translate.label.attr.clone:
- CAST/1550
- Clonality:
- Monoclonal
- Extra Details:
- Calpastatin is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal; calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion; mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits; designated Calpastatin; Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types; tissue type and erythrocyte type; resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization; such as the acrosome reaction.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human CAST protein
- Isotype:
- IgG1
- Molecular Weight:
- 126kDa
- Research Area:
- Cardiovascular; Defective Intrinsic Apoptosis; Infectious Disease; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123332
