KDM5C Antibody
Product Sizes
100 ug
£671.00
8242-MSM1-P1ABX-100UG
About this Product
- SKU:
- 8242-MSM1-P1ABX
- Additional Names:
- Histone demethylase JARID1C | Jumonji/ARID domain-containing protein 1C | Protein SmcX | Protein Xe169 | [histone H3]-trimethyl-L-lysine(4) demethylase 5C
- Application:
- Flow Cytometry
- translate.label.attr.clone:
- PCRP-KDM5C-1A11
- Clonality:
- Monoclonal
- Extra Details:
- SmcX; also known as JARID1C (jumonji; AT rich interactive domain 1C); MRXJ; KDM5C or XE169; is a nuclear protein that contains one ARID domain; one JmjC domain; one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle; SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3; thereby playing a role in the histone code; as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements; thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR); a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human KDM5C protein
- Isotype:
- IgG2c
- Molecular Weight:
- 176kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135251
