Recombinant Nectin 4 / Nectin Cell Adhesion Molecule 4 / PVRL4 Antibody
Product Sizes
100 ug
£671.00
81607-RBM7-P1ABX-100UG
About this Product
- SKU:
- 81607-RBM7-P1ABX
- Additional Names:
- Ig superfamily receptor LNIR | Nectin cell adhesion molecule 4 | Poliovirus receptor-related protein 4
- Application:
- Flow Cytometry, Immunohistochemistry
- translate.label.attr.clone:
- NECTIN4/13438R
- Clonality:
- Monoclonal
- Extra Details:
- Homologous to the poliovirus receptor (PVR/CD155); the nectin immunoglobulin superfamily comprises four known isoforms (-1; -2; -3; and -4). The ectodomain of nectin family members comprises three Ig-like domains (V; C; C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion; cellular morphogenesis and cellular differentiation. Nectin associates with the Actin cytoskeleton through its interaction with the Actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and Nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C'-C''-D b strands of the V domain of Nectin 1. Unlike other nectins; which are more widely expressed; Nectin 4 is mainly expressed in the placenta.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa266-280) of human NECTIN4 protein corresponding to the extracellular domain (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 66kDa
- Research Area:
- Angiogenesis; Cancer; Immuno Oncology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=148003
