Alpha Actinin 4 / ACTN4 Antibody
Product Sizes
20 ug
£364.00
81-MSM1-P0-20UG
About this Product
- SKU:
- 81-MSM1-P0
- Additional Names:
- Non-muscle alpha-actinin 4
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- 93
- Clonality:
- Monoclonal
- Extra Details:
- The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins; dystrophins and -actinins. There are four tissue-specific -actinins; namely -actinin-1; -actinin-2; -actinin-3 and -actinin-4; which are localized to muscle and non-muscle cells; including skeletal; cardiac and smooth muscle cells; as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain; two calponin-homology domains; two EF-hand domains and four spectrin repeats; through which they function as bundling proteins that can cross-link F-Actin; thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1); a common renal lesion characterized by decreasing kidney function and; ultimately; renal failure.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human ACTN4 protein
- Isotype:
- IgG1
- Molecular Weight:
- 105kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123275
