CD276 / B7-H3 Antibody
Product Sizes
100 ug
£671.00
80381-MSM5-P1-100UG
About this Product
- SKU:
- 80381-MSM5-P1
- Additional Names:
- 4Ig-B7-H3 | B7 homolog 3 | Costimulatory molecule
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- B7H3/4345
- Clonality:
- Monoclonal
- Extra Details:
- T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule; B7-H3 (B7-homolog 3; also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28; CTLA-4; ICOS and PD-1. Widely expressed on nonlymphoid tissues; B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer; implicating B7-H3 as a potential therapeutic tool.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa100-300) of human CD276 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- B7-H3 isoforms: 57/34/53/57 kDa; glycosylated B7-H3: 90-110 kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123243
