PD-L2 / PDCD1LG2 / CD273 Antibody
Product Sizes
100 ug
£671.00
80380-MSM6-P1-100UG
About this Product
- SKU:
- 80380-MSM6-P1
- Additional Names:
- BRCA1-associated protein 1 | Cerebral protein 6
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PDL2/2676
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of about 31kDa; which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation; cytokine production; differentiation of effector T cells and the induction of Bcl-x; a promoter of T cell survival. Conversely; engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28; cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart; lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 31kDa
- Research Area:
- Dendritic Cell Marker; Immunology; PD-1 blockade immunotherapy
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123242
