Calcitonin Antibody
Product Sizes
20 ug
£364.00
796-MSM4-P0-20UG
About this Product
- SKU:
- 796-MSM4-P0
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- CALCA/3310
- Clonality:
- Monoclonal
- Extra Details:
- Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones; calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen; which increases Calcitonin mRNA levels. The Calcitonin gene; CALCA; undergoes tissue-specific RNA alternative splicing; resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides; Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1; also designated CGRP1 or 伪-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid; while CGRP is produced in neuronal cells. A second CGRP related gene; CALCB; thought to be derived from an gene duplication event; has been identified in mouse; rat and human. Unlike CALCA; CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or 尾-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues; depending on the species.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human Calcitonin protein (around aa 3-116) (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 14.5kDa
- Research Area:
- Cardiovascular; Neuroscience; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123181
