Recombinant ZAP70 (Chronic Lymphocytic Leukemia Marker) Antibody
Product Sizes
100 ug
£768.00
7535-RBM14-P1-100UG
About this Product
- SKU:
- 7535-RBM14-P1
- Additional Names:
- 70 kDa zeta-chain associated protein | Syk-related tyrosine kinase
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MSVA-870R
- Clonality:
- Monoclonal
- Extra Details:
- ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa 247-382) of human ZAP70 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 70kDa
- Research Area:
- Cardiovascular; Immunology; PD-1 blockade immunotherapy; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=147582
