Recombinant ZAP70 (Chronic Lymphocytic Leukemia Marker) Antibody
Product Sizes
20 ug
£364.00
7535-RBM12-P0-20UG
About this Product
- SKU:
- 7535-RBM12-P0
- Additional Names:
- 70 kDa zeta-chain associated protein | Syk-related tyrosine kinase
- Application:
- ELISA, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- ZAP70/6492R
- Clonality:
- Monoclonal
- Extra Details:
- Zeta-associated protein-70 (ZAP-70) is a member of the Syk family of tyrosine kinases; a group of proteins that attach to the zeta chain components of T-cell receptors to signal downstream events involved in the regulation of cell function; proliferation; and death. Research suggests that the ZAP-70 protein may also play an important role in natural killer (NK) cell activation and early B-cell development; however; it is not expressed in most normal mature B-cells. Expression of ZAP-70 has been reported in various lymphomas; including mantle cell lymphoma; small lymphocytic lymphoma and marginal zone lymphoma. During thymocyte development; ZAP-70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally; ZAP-70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human ZAP70 protein (around aa 247-382) (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 70kDa
- Research Area:
- Cardiovascular; Immunology; PD-1 blockade immunotherapy; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=123036
