Recombinant XRCC5 (Ku86 / Ku80) (Thyroid-Lupus Autoantigen) Antibody
Product Sizes
20 ug
£364.00
7520-RBM13-P0-20UG
About this Product
- SKU:
- 7520-RBM13-P0
- Additional Names:
- 86 kDa subunit of Ku antigen | ATP-dependent DNA helicase 2 subunit 2 | ATP-dependent DNA helicase II 80 kDa subunit | CTC box-binding factor 85 kDa subunit | DNA repair protein XRCC5 | Ku80 | Ku86 | Lupus Ku autoantigen protein p86 | Nuclear factor IV | Thyroid-lupus autoantigen | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- XRCC5/8703R
- Clonality:
- Monoclonal
- Extra Details:
- The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome; and was later found in the sera of patients with other rheumatic diseases. Ku has several functions; including cell signaling; DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity; serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa300-500) of human XRCC5 (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 80-86kDa
- Research Area:
- Immunology; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130306
