Vinculin (Marker of Age-related Macular Degeneration) Antibody
Product Sizes
20 ug
£364.00
7414-MSM5-P0-20UG
About this Product
- SKU:
- 7414-MSM5-P0
- Additional Names:
- Metavinculin
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- VCL/3617
- Clonality:
- Monoclonal
- Extra Details:
- This antibody recognizes both Vinculin (125kDa) and meta-Vinculin (135kDa). Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo; these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal; focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins; including Talin and 伪-Actinin. In addition; vinculin; Talin and 伪-Actinin each contain Actin binding sites. Expression of vinculin and Talin have been shown to be affected by the level of Actin expression. 伪-Actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and Talin complex or by a direct interaction with integrin.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human Vinculin protein (VCL)
- Isotype:
- IgG1
- Molecular Weight:
- 125-135kDa
- Research Area:
- Cardiovascular; Immunology; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122765
