Recombinant Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody
Product Sizes
20 ug
£364.00
7306-MSM22-P0-20UG
About this Product
- SKU:
- 7306-MSM22-P0
- Additional Names:
- Catalase B | Glycoprotein 75 | Melanoma antigen gp75 | Tyrosinase-related protein 1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rG3E6
- Clonality:
- Monoclonal
- Extra Details:
- Tyrosinase-related protein-1 (TRP-1) is a member of a family of proteins which are involved in melanin biosynthesis. The catalytic function of TRP-1 has not been fully resolved but the enzyme appears to be important in the oxidation of 5;6-dihydroxyindole-2-carboxylic acid to form a high molecular weight pigmented biopolymer. In mammals; there are two basic types of melanin; the brown-black eumelanin and the reddish-yellow phaeomelanin. The concentrations of each are variable and are not related to skin type. In skin exposed to suberythemal doses of UVB; an increase in the number of melanocytes expressing TRP-1 and TRP-2 was observed with no increase noted in the number of tyrosinase-expressing melanocytes. In normal; untreated skin the number of melanocytes which immunohistochemically stain for either TRP-1; TRP-2 or tyrosinase appears to be similar irrespective of skin type. TRP-1 is also expressed in more than 50 per cent of choroidal melanocytes of the adult eye.
- Host:
- Mouse
- Immunogen:
- Prokaryotic recombinant fusion protein corresponding to the C-terminus of the TRP-1 molecule
- Isotype:
- IgG2a
- Molecular Weight:
- 75kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=146493
